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IJMS Webinar | Transporters for Organic Cations

08/06/2021 17:00

Physiology of Transporters for Organic Cations, Biochemistry of Transporters for Organic Cations, Pharmacology of Transporters for Organic Cations
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Webinar Information

2nd Webinar of International Journal of Molecular Sciences

Transporters for Organic Cations

This webinar introduces the second volume of the Special Issue "Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations" of the International Journal of Molecular Sciences. Transporters for organic cations belong to the solute carrier (SLC) group. Among their substrates, there are important neurotransmitters, such as acetylcholine, dopamine, histamine, and serotonin, and metabolic products, such as creatinine, and also many drugs and xenobiotics such as metformin and paraquat. Therefore, transporters for organic cations have important physiological and pharmacological roles. In this webinar, Dr. Ciarimboli will introduce the general physiological and pharmacological properties of these transporters. Dr. Daws will present their physiological roles for neurotransmitter signaling in the brain. Then Dr. Indiveri will discuss physiological and pharmacological properties of organic cation transporters, novel (OCTN). Finally, Dr. Visentin will illustrate the role for transporters of organic cations in cancer. After every presentation time for discussion with participants will be available.
In this webinar integrative aspects of physiological, pharmacological, and toxicological roles of transporters for organic cations will be presented and discussed. Therefore, the webinar is of interest both for researcher, who just begin to work in this field, but also to expert researcher, who would like to reach a broader understanding of the properties of transporters for organic cations.

Prof. Dr. Giuliano Ciarimboli
Experimental Nephrology, Department of Internal Medicine D,
University Hospital Münster,
Münster, Germany

Date: 8 June 2021

Time: 5:00 pm CEST

Webinar ID: 828 5622 3456

Webinar Secretariat: [email protected]

Chair: Prof. Dr. Giuliano Ciarimboli

The following experts will present and talk:

Prof. Dr. Giuliano Ciarimboli, University Hospital Münster,
Münster, Germany

Giuliano Ciarimboli studied Biology at Pisa University (Italy) and was a scholarship holder at the Institute of Clinical Physiology of the Italian Research Council (Consiglio Nazionale delle Ricerche, CNR) in Pisa from 1989 to 1994. During this time, he was involved in the study of endogenous digitalis-like factors and of pulmonary metabolism of basic amines. From 1995 to 1999 he worked in the laboratory of Prof. Stolte at the Hannover Medical School (Germany) and investigated the role of charge, dimension and conformation of proteins in the glomerular filtration. In 1999 the University of Hannover (Germany) awarded him a PhD degree in natural sciences. In 2001 he joined the group of Prof. Schlatter (Experimental Nephrology at the Münster University Clinic, Germany). Dr Ciarimboli currently holds the position as Professor at the Medizinische Klinik D, Exp. Nephrologie at Universitätsklinikum Münster in Münster, Germany. His research interests include regulation of organic cation transporters and their interaction with drugs. He has published 75 original refereed research papers, 12 peer reviewed reviews, 6 book chapters (Hirsch index = 26).

Prof. Dr. Lynette C. Daws, University of Texas Health, San Antonio, TX, USA

Dr. Daws obtained her PhD in neuropharmacology at the Flinders University of South Australia. She is currently the Frost Bank Distinguished Professor in Biomedical Sciences in the Departments of Cellular & Integrative Physiology and Pharmacology at the University of Texas Health Science Center at San Antonio in the United States. Dr. Daws is interested in the role of organic cation transporters in maintaining monoamine homeostasis in brain. She applies primarily in vivo electrochemical (high-speed chronoamperometry), ex vivo neurochemical and behavioral methods to her research, using a combination of genetic and pharmacological approaches. Dr. Daws and her collaborators have revealed organic cation transporter 3 as a potential target to improve therapeutic interventions for the treatment of depression, and as a site of action for amphetamine and related psychostimulants. Her findings encourage further research into organic cation transporters as novel targets for the treatment of psychiatric disorders and addiction to amphetamine-like drugs.

Prof. Dr. Cesare Indiveri, University of Calabria, Arcavacata di Rende, Italy; CNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), Bari, Italy

Cesare Indiveri is PI of the Biochemistry and Molecular Biotechnology Unit, University of Calabria. He is an expert in the field of membrane transporters. Since 1988 he was a researcher in the National Research Council (IBIOM, Bari). In 2000, he moved to the University of Calabria where he is a full Professor in Biochemistry. Cesare Indiveri supervised several PhD students and more than 100 undergraduate students for master thesis. His research interests cover several aspects of nutrition and metabolism in health and diseases with particular reference to absorption, distribution and excretion of nutrients and drugs. Indiveri is also involved in drug design and with his group created a platform for drug-transporter interaction testing, based on protein expression, purification and functional assay in vitro/ex vivo systems. Over the years, Indiveri created a network of international collaborations with experts in the fields of membrane transporters. Indiveri is co-author of more than 150 peer review papers, among which relevant papers on Nature, Nature Communication, Scientific Reports and Cell; he is co-inventor of an international patent. Indiveri is a member of several scientific associations.

Dr. Michele Visentin, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Born in Venice (Italy), Dr. Visentin earned a bachelor’s degree in molecular biology from the University of Padua, a master’s degree in molecular medicine from the University of Trieste and a PhD in biochemistry and pharmacology from the University of Udine. His interest in the study of membrane transporters began after joining, as visiting graduate student, the research group of I. David Goldman at the Albert Einstein Medical College in New York, where he developed expertise in biochemistry of transport that became the backbone of his current research. After postdocs at the Albert Einstein Medical College in New York and at the University of Zurich, Dr. Visentin is now group leader in the Department of Clinical Pharmacology and Toxicology of the University Hospital of Zurich, where his main focus is elucidating novel biochemical features of the organic cation transporters and the pathological and pharmacological ramifications thereof.

Program

Speaker/Presentation

Time in CEST

Prof. Dr. Giuliano Ciarimboli

Chair Introduction

5:00 – 5:05 pm

Prof. Dr. Giuliano Ciarimboli

The General Physiological and Pharmacological Properties of Transporters for Organic Cations

5:05 – 5:25 pm

Prof. Dr. Lynette C. Daws

Organic Cation Transporters in Psychiatric and Substance Use Disorders

5:25 – 5:45 pm

Prof. Dr. Cesare Indiveri

The SLC22A4 Alias OCTN1 Transporter: Novel Findings and Dark Sides

5:45 – 6:05 pm

Dr. Michele Visentin

Organic Cation Transporters in Pathology, Imaging, and Current Therapy of Cancer

6:05 – 6:25 pm

Q&A Session & Discussion

6:25 – 6:55 pm

Closing of Webinar
Prof. Dr. Giuliano Ciarimboli

6:55 – 7:00 pm

Webinar Content

On Tuesday 8 June 2021, MDPI and the International Journal of Molecular Sciences organized their second webinar, entitled "Transporters for Organic Cations".

Prof. Dr. Giuliano Ciarimboli, Professor at the Medizinische Klinik D, Exp. Nephrologie at Universitätsklinikum Münster in Münster, Germany, and as the Chair of the webinar, offered an overview of the topic, and presented the panel of speakers selected for the event. He disserted on "the General Physiological and Pharmacological Properties of Transporters for Organic Cations", during the first talk of the session.

After him it was the turn of Prof. Dr. Lynette C. Daws, Frost Bank Distinguished Professor in Biomedical Sciences in the Departments of Cellular & Integrative Physiology and Pharmacology at the University of Texas Health Science Center at San Antonio (USA). She focused the topic of her talk on the psychiatric field with her talk entitled "Organic Cation Transporters in Psychiatric and Substance Use Disorders".

Prof. Dr. Cesare Indiveri
from University of Calabria and CNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), in Italy, gave the following talk. Cesare contributed to the discussion with his presentation entitled “The SLC22A4 Alias OCTN1 Transporter: Novel Findings and Dark Sides”.

The fourth and last presentation with the title "Organic Cation Transporters in Pathology, Imaging, and Current Therapy of Cancer" was held by Dr. Michele Visentin, Group Leader in the Department of Clinical Pharmacology and Toxicology of the University Hospital of Zurich. The focus of his laboratory's research is elucidating novel biochemical features of the organic cation transporters and the pathological and pharmacological ramifications thereof.


The presentations were followed by a Q&A and a discussion, moderated by the Chair. The webinar was offered via Zoom and required registration to attend. The full recording can be found here on Sciforum website. In order to stay updated on the next webinars on IJMS, be sure to sign up for our newsletter by clicking on “Subscribe” at the top of the page.

Relevant Special Issues

Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations 2.0
Guest Editor: Prof. Dr. Giuliano Ciarimboli
Deadline for manuscript submissions: 31 October 2021

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